Boldo extract has potent anti-urease activity and anti-adherent effect against H. pylori, a cause of stomach ulcers and increased cancer risk (Phyto. Res)

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Boldo extract has potent anti-urease activity and anti-adherent effect against H. pylori, a cause of stomach ulcers and increased cancer risk (Phyto. Res)

Author: AHPA Staff/Friday, June 6, 2014/Categories: Science Alert

Editor's Note: Aqueous extract of the dried leaves of Peumus boldus exhibited high anti-urease activity and anti-adherent effect against Helicobacter pylori, a major cause of stomach and duodenal ulcers and increased risk of stomach cancer. A fraction rich in proanthocyanidins was obtained following bioassay-guided fractionation and was considered the cause of this activity.

Phytotherapy Research

DOI: 10.1002/ptr.5176

Boldo extract has potent anti-urease activity and anti-adherent effect against H. pylori, a cause of stomach ulcers and increased cancer risk 

Abstract

In this work, the anti-Helicobacter pylori effect of an aqueous extract from dried leaves of Peumus boldus Mol. (Monimiaceae) was evaluated. This extract displayed high inhibitory activity against H. pylori urease. Therefore, in order to clarify the type of substances responsible for such effect, a bioassay-guided fractionation strategy was carried out. The active compounds in the fractions were characterized through different chromatographic methods (RP-HPLC; HILIC-HPLC). The fraction named F5 (mDP = 7.8) from aqueous extract was the most active against H. pylori urease with an IC50 = 15.9μg gallic acid equivalents (GAE)/mL. HPLC analysis evidenced that F5 was composed mainly by catechin-derived proanthocyanidins (LC-MS and phloroglucinolysis). The anti-adherent effect of boldo was assessed by co-culture of H. pylori and AGS cells. Both the aqueous extract and F5 showed an anti-adherent effect in a concentration-dependent manner. An 89.3% of inhibition was ... extract. In conjunction, our results suggest that boldo extract has a potent anti-urease activity and anti-adherent effect against H. pylori, properties directly linked with the presence of catechin-derived proanthocyanidins. 

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