AHPA updates 14 entries to the online Botanical Safety Handbook, 2nd ed. in final 2022 release

Oregon grape and pinellia among recently updated entries

December 21, 2022

The American Herbal Products Association (AHPA) has released updates to 14 botanicals via the online Botanical Safety Handbook, 2nd ed. In 2022, 44 entries in the online Botanical Safety Handbook have been updated, and two have been added. Since 2018, when revisions to the online Botanical Safety Handbook were initiated, 127 entries have been updated, and six new entries have been added.
The following online entries have been updated in this final 2022 release:

  • Artemesia annua (sweet wormwood) – A literature review identified numerous clinical trials, toxicity studies, and safety information regarding use of artemisinin for the treatment of malaria during pregnancy.

  • Baptisia tinctoria (wild indigo) – A review identified a new clinical trial for wild indigo.

  • Berberis spp. (Oregon grape) – This review incorporated a change in botanical nomenclature to Berberis spp. (formerly Mahonia spp.) and added clinical trial information and a human pharmacology study.

  • Castanea sativa (Spanish chestnut) – A review of recent literature identified genotoxicity and cytotoxicity studies.

  • Ceanothus americanus (red root) – A review identified additional secondary references on use during pregnancy.

  • Corydalis yanhusuo (corydalis) – A literature review identified an animal interaction study, a systematic review of hepatotoxicity case reports, animal pharmacology, and toxicity studies.

  • Maranta arundinacea (arrowroot) – New clinical trial and acute toxicity studies were identified in the most recent review.

  • Menyanthes trifoliata (bog bean) – A recent review added cytotoxicity studies.

  • Mitchella repens (partridge berry) – An animal pharmacology study was added during the most recent review.

  • Morella spp. (bayberry) – A literature review did not identify any new relevant safety information for bayberry.

  • Morus alba (white mulberry bark) – A new animal pharmacology study was identified in the most recent review.

  • Morus alba (white mulberry fruit) – A review identified new animal pharmacology and toxicity studies.

  • Morus alba (white mulberry twig) – The most recent review added references for human and animal pharmacology and acute toxicity.

  • Pinellia ternata (pinellia) – A recent review amended the Safety class to 2d (previously Safety class 3) and added an analytical reference and toxicity studies.

AHPA members can obtain a hard copy or an annual individual subscription to the online Botanical Safety Handbook for $95.00, with multi-user rates available for companies needing expanded access. Information about hard copy purchases and subscriptions can be found on the AHPA website.
Subscribers to the online Botanical Safety Handbook can review short descriptions of updated entries in the "Revisions" panel on the online version homepage when they log in. The online Botanical Safety Handbook is undergoing review of existing entries and the addition of new entries to provide the latest safety information before it can be included in the next print edition of the handbook. AHPA will continue to post additional updates to existing entries as well as develop new botanical entries. Current subscribers are notified of these updates when they become available.
AHPA's Botanical Safety Handbook is an essential tool for anyone who manufactures, recommends, or uses herbal products. The handbook provides safety information on over 500 species of herbs, derived from data compiled from clinical trials, pharmacological and toxicological studies, medical case reports, and historical texts. All entries are reviewed by an Expert Advisory Council that includes some of the most renowned herbal and integrative medicine experts in the United States.




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