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AHPA updates seven entries to the online Botanical Safety Handbook, 2nd Ed. and expands mushroom entries

New entry for lion's mane underscores continued consumer interest in functional mushroom products

July 9, 2024

The American Herbal Products Association (AHPA) has released updates to seven botanicals via the online Botanical Safety Handbook, 2nd Ed., as well as added a new entry for lion's mane mushrooms.
 
The following online entries have been updated or added in this release:

  • Atropa belladonna (belladonna) – Updates to this entry identified U.S. FDA safety releases about belladonna homeopathic products and numerous reports of accidental ingestions.

  • Azadiracta indica (neem bark) – Review for neem bark added references for adverse events in clinical trials and case reports, human and animal pharmacology studies, and toxicity studies.

  • Azadiracta indica (neem leaf) – Review for neem leaf added references for an animal drug interaction study, reports of adverse events in clinical trials, human and animal pharmacology studies, animal reproductive studies, and toxicity studies.

  • Boswellia spp. (boswellia) – Recent review for boswellia added adverse events in clinical trial references, human and animal pharmacology studies, and toxicity studies.

  • Bupleurum spp. (bupleurum) – References for an epidemiological study and toxicity studies were added to this entry. Processing information for bupleurum root was added to the Editors' Notes.

  • Buxus semperivens (boxwood) – In vitro pharmacology and cytotoxicity studies were added to this entry.

  • Cetraria islandica (Iceland moss) – Review of this botanical added an historical food use reference and genotoxicity and cytotoxicity references.

  • Hericium erinaceus (lion's mane) – This new entry includes documentation of food use, clinical trial and adverse event reports, pharmacology studies, and toxicity studies.

 
AHPA members can obtain an annual individual subscription to the online Botanical Safety Handbook or a hard copy for $95.00, with multi-user rates available for companies needing expanded access. Information about subscriptions and hard copy purchases can be found on the AHPA website.
 
Subscribers to the online Botanical Safety Handbook can review short descriptions of updated entries in the "Revisions" panel on the online version homepage when they log in. The online Botanical Safety Handbook is undergoing review of existing entries and the addition of new entries to provide the latest safety information before it can be included in the next print edition of the handbook. AHPA will continue to post additional updates to existing entries as well as develop new botanical entries.
 
AHPA's Botanical Safety Handbook is an essential tool for anyone who manufactures, recommends, or uses herbal products. The handbook provides safety information on over 500 species of herbs, derived from data compiled from clinical trials, pharmacological and toxicological studies, medical case reports, and historical texts. All entries are reviewed by an Expert Advisory Council that includes some of the most renowned herbal and integrative medicine experts in the United States.

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